Years back, some sites like Silk Road and others were used for shipping marijuana through hidden online channels. Later when the FBI seized, and consequently shut down these sites, the black market marijuana supply took a hit. Some how, sellers have become smarter, and Silk Road 2 has showed up with an advanced decentralized encryption.
Pharmacodynamics: effects and mechanisms of cannabinioids
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Cannabinoids have received a lot of attention in recent years, due to the legalization of cannabis that is affecting the US. UU., Scientific research on its effects or the growing popularity of hemp and CBD. This attention is found in constant discoveries, of which most appear to be positive, at least initially. Therefore, it seemed a good idea to take a look at the long-awaited pharmacodynamics of cannabinoids, that is, their mechanisms and effects.marijuana online
A look at the mechanisms of cannabiniods
Cannabis cannabinoids interact with the body by binding to the receptors of the endocannabinoid system. A system that all human beings have and that is found throughout the body. Our body naturally produces its own version of cannabinoids that interact with the system, but if external varieties are added, the stimulation of the system increases.
In the endocannabinoid system, there are two main types of known receptors (the discovery of this system is relatively new). The first is the CB1 receptor. CB1 receptors are found mainly in the brain, central nervous system, and related organs. They are believed to play an important role in functions such as sleep, appetite, mood and pain perception.
The other type of receptors that cannabinoids interact with are known as CB2 receptors. These are found throughout the body, especially in the immune system, the gastrointestinal system, and its related organs. It is believed that the activation of these receptors helps modulate inflammation, reducing its severity. marijuana online
Effects of the 5 main cannabinoids
Although much more complicated, the above summarizes the mechanics of how cannabinoids interact with the body. So it’s time to take a look at some of its effects. It should be noted that the following effects are still being studied and that new interactions are discovered every day, which helps us understand their true effects. marijuana online
THC is undoubtedly the most famous cannabinoid of all. It is also usually the most common cannabis cannabinoid. In hemp, it is only present in small amounts, so small that it is often considered legal. THC is psychoactive, which allows its consumers to feel “established.” In addition, it is also believed to offer pain relief, stimulate appetite, reduce nausea and suppress muscle spasms. marijuana online
Possibly the second most famous cannabinoid, CBD is not psychoactive, which means that its consumption does not take place. It is found in both hemp and cannabis in large quantities.
It is believed that the main effects of CBD are inflammation reduction, pain relief, appetite stimulation, nausea reduction, anxiety reduction, psychosis management, reduction of frequency of seizures, suppression of muscle spasms and reduction of growth bacteria, to name a few. As you can see, CBD is the focus of scientific research for good reason.
CBC, although present in small amounts, remains much longer in the bloodstream than other cannabinoids. This makes its effects last longer. It is believed to provide pain relief, reduce inflammation, retard bacterial growth and promote bone formation.
CBG acts as a stem cell for other cannabinoids, such as THC, CBC, and CBD. As the hemp plant grows, the CBG becomes each one. Therefore, when the time comes to harvest, there is hardly anything left at the plant. It is believed that its effects are pain relief, inflammation reduction, healthy bone growth and that it has the ability to fight fungal infections.
CBN occurs when THC is exposed to oxygen. The result is a calming effect. Therefore, it is associated with pain relief, reduction of muscle spasms and improvement of sleep. When cannabis consumed, it is partly responsible for the lethargic or “sofa” effect that is sometimes experienced.
As you can see, there is much to learn about cannabinoids and how they interact with our bodies. The pharmacodynamics of cannabinoids is a very complex issue. We hope that the above serves as a brief description of what happens, but if you want to know, there is much more to read.This entry was posted in Uncategorized and tagged cannabiniods, effects and mechanisms of cannabiniods, mechanisms of cannabiniods.
These are the 9 most popular weed strains in Colorado
Recreational marijuana has been on the Colorado market for over two years now, and we’re starting to get some interesting data about the preferences of its consumers.
Tradiv, an online cannabis-distribution platform, and BDS Analytics, a cannabis-focused analytics company, teamed up to release a report outlining the most popular marijuana strains in the legal Colorado market.
Marijuana comes in two distinct species, sativa and indica, and they’re thought to have different effects on your mind and body.
Many of those effects, however, are user-reported, and the science isn’t totally clear on how the particular compounds in the marijuana actually interact with your brain, as Business Insider’s Melia Robinson reported.
Generally speaking, sativa strains are considered to be energizing “head” highs, while indica strains are more subdued “body” highs, helpful for putting you to sleep.
Blue Dream, the top-selling strain, is a “pretty potent sativa,” John Manlove, the director of sales at Tradiv told Business Insider over the phone.
Consumers like it because it gives them an “energetic” high, Manlove said. But it’s not only popular because of consumers — it’s also easy to grow and cultivate.
“It’s not a fickle strain,” Manlove said. “It’s not very susceptible to mold and pests, and the common stresses on a plant.”
More importantly, it’s a high-yielding strain, so for cultivators, the economics of growing Blue Dream make sense.
The report itself is based off of point-of-sale data from a sample of Colorado cannabis retailers that represent 15% to 20% of the market. The sample was then fed through a proprietary algorithm to represent the whole market, Liz Stahura, the vice president of BDS Analytics, told Business Insider in an email.
See the 9 top-selling strains in Colorado below
Editor’s note: While the science remains murky and various strains affect different people in different ways, we pulled product descriptions from Leafly, a popular strain-reviewing website.
Hell’s Angel OG is an indica-dominant hybrid strain, which produces large, heavy buds, and its effects hit you “quickly and heavily.”
8. Green Crack
Green Crack is a sativa strain that will give smokers a strong burst of energy. It’ll help you increase your focus during the day.
Northern Lights is a pure indica strain. It’s known for its relaxing effects, which cause a “dreamy euphoria” that “settles in the body.” It’s good for relieving stress and helping you sleep after a long day.
6. Girl Scout Cookies
Girl Scout Cookies is a cross between OG Kush and Durban Poison, and it’s bred for maximum potency. This strain is known for its high THC content — marijuana’s active ingredient.
5. Blueberry Diesel
Blueberry diesel is a cross between two strains, blueberry and sour diesel. The strain gets its name from the buds, which give off a pungent, blueberry-like odor
4. Sour Diesel
Sour diesel is another sativa strain, and it’s a popular strain for medical patients dealing with anything from stress to depression and chronic pain.
3. Bruce Banner #3
Bruce Banner #3 is one the three main varieties of the Bruce Banner strain. It’s a potent hybrid strain (meaning it was originally bred from both sativa and indica plants), and it’ll give you a “euphoric” buzz.
2. Durban Poison
Durban Poison is a sativa popular for its “uplifting and energetic” effects. It’s a good strain to consume during the day to maintain productivity and boost creativity.
1. Blue Dream
Blue Dream is a sativa-dominant strain that blends “full-body relaxation” with “gentle cerebral invigoration.”